Expression profiling projects and custom cDNA arrays


Genes expressed in inner ear

The following list was comprised from various sources indicating that the genes are either expressed in the inner ear(1), expressed in the human cochlea (2), or contain mutations resulting in deafness in humans (3).
  1. http://www.ihr.mrc.ac.uk/hereditary/genetable/index.html
  2. http://hearing.bwh.harvard.edu/estinfo.HTM
  3. http://dnalab-www.uia.ac.be/dnalab/hhh


GenBank Acc.No.DescriptionFunction
Y16281 acetylcholine receptor alpha 2 neural
Y08418 acetylcholine receptor alpha 3 neural
U62433 acetylcholine receptor alpha 4 neuronal
U62437 acetylcholine receptor beta 2 neuronal
Y08417 acetylcholine receptor beta 3 neural
X63432 actin,beta
AF006083 actin related prot.3actin filament assembly
Z22534 activin receptor like kinase 2cell surface receptor
D31770 Activin receptor type II AReceptor
AB008681 activin receptor type IIB
L12234 exon 1 aggrecan1structural prot.
X06268 alpha 1, stickler synd.fetal collagen, also found in blood
J03464 alpha 2major collagen of skin, bone, tendon
U76669 anion exchanger member 2, (SLC4A2)channel prot.
X05908 annexin 1possible anti-inflammatory activity.
D00017 annexin 2memb. binding prot.
M20560 annexin 3phospholipid binding prot.
M82809 annexin 4
J03578 X77673 annexin 6
L22474 apoptosis regulator
AF013263 apoptotic protease activating factor 1activation of caspase-3
AC005155 genomic aquaporin 1
AB001325 partial aquaporin 3water channel
U46566 exon 1 aquaporin5
ARP3
L08424 ASH1, achaet scute homolog 1trxn factor
U77629 ASH2trxn factor
U61148 ATOH1, HATH1HLH trxn factor
M90658 part. genomic ATP1A3Na,K-ATPase
M83363 (?) ATP2B4Ca-ATPase
M81181 ATPB2
X15357 atrial natriuretic peptide A receptor NPR1peptide receptor
AH005295 B-amyloid precursor protein, APP
J04513 basic fibroblast growth factorheparin binding growth factor
baxbcl2 assoc. X prot.
L13689 BMI-1trxn factor
M22489 BMP2
M22491 BMP3
D49493 BMP3binduces cart. + bone formation
D30751 BMP4
M60314 BMP5
NM_001718.2 BMP6
X51801 BMP7 (OP-1)
M97016 BMP8
Z22535 BMPR1A
U89326 BMPR1BReceptor
D50516 BMPR2
L33477 Br-cadherin
M61181 brain derived neurotrophic factor (BDNF)growth factor
V01512 c-fostrxn factor
J04111 c-juntrxn factor
L16785 c-myctrxn factor
Z28609 partial Ca channel subunit voltage dependent alpha 2
L29384 Ca channel,volt. dependent alpha 1E (CACNA1E)channel prot
Z74996 CACNA1CCa channel
L34058 cadherin-13
X06661 calbindinCa ATPase + 3',5' cyclic nucleotide phosphodiesterase
D45887 calmodulinCa binding
L14778 calmodulin dependent prot. phosphatase catalytic subunitputative role in calmodulin activat. of calcineuin
M81457 calpactin 1 light chainCa binding complex; reg. prot. phosphorylation
S737751 calsequestrin 1Ca binding regulatory prot.
D55655 calsequestrin 2
Y00339 carbonic anhydrase IIcauses osteopetrosis w/ renal tubular acidosis
M29458 carbonic anhydrase IIIreversible hydration of carbon dioxide
S72008 CDC 10 homologcell cycle control
L29222 CDC like kinase (CLK1)putative modulator of gamma interferon induced cell death
AF011794 cell cycle progression restoration 8 prot
S74445 cellular retinoic acid binding prot. 1 (CRABP1)
M68867 cellular retinoic acid binding prot. 2 (CRABP2)transporter
M11433 cellular retinol binding prot.
X60542 ciliary neurotrophic factor
X14723 clusterinsulfated glycoprot.
AF006740 COCH, DFNA9extracell. matrix molecule
collagen type I
M32798 collagen type I alpha 1
collagen type II
X14420 collagen type III alpha 1
M26576 collagen type IV alpha 1
X05610 collagen type IV alpha 2
X80031 collagen type IV alpha 3, Alp. syn.
X81053 collagen type IV alpha 4, Alp. syn.
U04520 collagen type IV alpha 5, Alp. syn.
M76729 collagen type V alpha 1
X15880 collagen type VI alpha 1
J04177 collagen type XI alpha 1, stickler synd.
J04974 collagen type XI alpha 2, stickler synd.
X75308 collagenase 3degrades collagen type 1
L41162 collagenIX alpha 3
U17278 collapsin response mediator prot. 1regulatory prot.
M92934 connective tissue growth factorinvolved in connective tissue growth
M86849 connexin 26, GJB2, DFNB1, DFNA3gap junction prot.
AJ005585 connexin 30, GJB6
AF099730 connexin 31, GJB3, DFNA2gap junction prot.
AF099731 connexin 31.1, GJB5
M96789 connexin 37, GJA4
U03486 connexin 40, GJA5
X52947 U64573 connexin 43, GJA1gap junction prot.
AF075290 connexin 46, GJA3
AF217524 connexin 50, GJA8
U53328 cyclin Gassoc. w/ growth stimulation
U11791 cyclin Hregulator of CDK activating kinase
X89713 death assoc. prot. 5putative modulator of gamma interferon induced cell death
AB004066 DEC1helix-loop-helix expressed in chondrocytes
L01131 decorincollagen binding prot.
D15057 defender against death 1 (DAD1)defect triggers apoptotic death
Z12172 delta like homolog 1
U66035 DFN1,DDP
AF051782 DIAPH1, DFNA1cytoskeletal prot.
U46461 dishevelled 1
AF006012 dishevelled 2
AF006013 dishevelled 3
U51003 DLX2
AF028233 DLX3
U73328 DLX4
AC004774 DLX5
AC004774 DLX6
AF028235 DLX7
U32944 dynein light chain 1microtubule motor
L19711 dystroglycan DAG1laminin binding prot. links cytoskel+ECM
M18533 dystrophin
U43519 dystrophin related protein 2memb. assoc. prot.
Z13009 e-cadherinCa-dependent cell adh. mol. involved in cell-cell interaction
M80583 X52541 early growth response prot. 1trxn factor activates genes of differentiation
X68879 EMX1trxn factor
X68880 EMX2trxn factor
X52001 endothelin 3ligand (WSIV)
L06622 endothelin A receptor
X61950 endothelin-1 receptoractivates phosphatidylinositol-Ca 2nd mess. sys.
L06623 endothelin-B receptorvasoactive peptide receptor
NM_001955 endothelin1
M57730 ephrin A1ligand of tyr. kinase receptor
AJ007292 ephrin A2
AJ006352 AJ006353 ephrin A4ligand of tyr. kinase receptor
U26403 ephrin A5
L36642 ephrin receptor A7
U48722 epidermal gr. fact. receptor. (EGFR)
X04571 epidermal growth factor
X00588 epidermal growth factor receptor
AB011536 epidermal growth factor-like 1
AB011539 epidermal growth factor-like 3
AB011541 epidermal growth factor-like 4
AB011542 epidermal growth factor-like 5
U77085 epithelial memb. prot. CL-20PMP family
M11730 ERBB2
M29366 ERBB3
L07868 ERBB4
L11284 ERK activator kinase (MEK1)
X80692 extracellular signal related kinase ERK3
Y10260 eyes absent homolog (EYA1A), BOR synd.trxn factor
X51521 ezrinECM
X51943 FGF1
AF010187 FGF1 intracell. binding prot.
M37825 FGF5
U47011 FGF8
M34641 FGFR1
M87770 FGFR2
M58051 FGFR3
AF202063 FGFR4
X02761 fibronectin
U13224 FKHL10, FREAC6winged helix trxn factor
M18627 Fodrin, spectrin alphastructural prot.
M19480 follistatin
D89937 follistatin related protein
S65762 Fordrin, spectrin beta
M38684 formin, limb deformity prot. (FMN)formin prot.
U13219 FREAC1
U13220 FREAC2
U59831 FREAC4
U68057 frezzled (fre)involved in differentiation
AB017363 frizzled 1WNT receptor
AB017364 frizzled 2WNT receptor
U82169 frizzled 3 (9)
AB032417 frizzled 4
U43318 frizzled 5
AB012911 frizzled 6
AB017365 frizzled 7WNT receptor
AF026692 frizzled related prot.tissue polarity gene
M16538 G-protein beta 2
M31328 G-protein beta 3
AF017656 G-protein beta 5
U31383 G-protein gamma 10
U31384 G-protein gamma 11
U31382 G-protein gamma 4
AF085709 G-protein gamma 5
AB010414 G-protein gamma 7
M25667 GAP43
X58072 GATA3zinc finger trxn factor
X04412 gelsolinactin filament regulation
X07384 GLItrxn factor
AB007295 GLI2trxn factor
M57609 GLI3
L19063 glial cell line derived neurotrophic factor
J04569 glial fibrillary acidic protein-like
M10901 glucocorticoid receptor alphatrxn factor
M11050 glucocorticoid receptor betazinc finger trxn factor
X87237 glucosidase I
U96402 goosecoid-liketrxn factor
M81886 GRIA1
U10301 GRIA3
U16129 GRIA4cell adhesion molec.
AF001954 growth inhibitor p33ING1possible tumor suppressor
U10550 GTP binding prot. GEMmemb. assoc.; receptor mediated signal transduc.
M27543 guanine nucleotide binding protein G(i) alpha
X07036 guanine nucleotide binding protein G(S), alpha subunitactivates cyclase in response to b-adrenergic stimuli
U02081 guanine nucleotide regulatory prot. NET1
L19314 Hairy homolog (HRY)
S60110 heparin binding neurite outgrowth promoting factorneural cell migration
J04621 heparin sulfate proteoglycan core prot.integral memb. proteoglycan
M73240 U11813 (alt. splice) hepatocyte growth factor
J02958 hepatocyte growth factor receptor (MET)
U14325 U14326 U14327 HLX1, Hairy homolog
D63874 HMG-1trxn factor
J02621 HMG-14trxn factor
M12623 HMG-17trxn factor
M75952 HOX11
U10421 HOXA1
U58089 Hs-cul-3human homolog of negative reg. of cell cycle in Ce.
X06990 ICAM1
L38517 partial indian hedgehog
U45879 inhibitor of apoptosis prot. 2homologous to neuronal apoptosis inhib. prot.
X04434 M69229 insulin like gr. fact. receptor 1
Y00285 insulin like gr. fact. receptor 2
X57025 insulin like growth factor 1growth promoting activity
J03242 insulin like growth factor 2
M59316 insulin like growth factor binding prot. 1
M35410 insulin like growth factor binding prot. 2
M35878 insulin like growth factor binding prot. 3
Y12508 insulin like growth factor binding prot. 4
L27560 insulin like growth factor binding prot. 5
M69054 insulin like growth factor binding prot. 6
S75725 insulin like growth factor binding prot. 7
M10051 insulin receptor
L19440 partial integrin alpha 1
M27492 interleukin 1 receptorbinding leads to NK-kB activation
U62858 interleukin 13 receptor
U12507 inward rectifier K+ channel (KCNJ2)
U07559 ISL1LIM homeodomain trxn factor, zinc finger
AF028593 jagged 1/serratetransmemb. receptor
AF020201 jagged 2, serrate
U07364 K+inward rectifying channel J4 (KCNJ4)
M97252 KAL1, Kallman syndrome
L28168 KCNE1, JLN synd.
U89364 KCNQ1
AF105202 KCNQ4, DFNA2
M60828 keratinocyte growth factorrelated to fibroblast gr. fact.
Z22551 kinectinkinesin receptor
X84849 partial KIP1, CDKN1B, p27kinase
U63834 X65959 KIT
AJ006345 KVLQT1, JLN synd.same as kcnq1 ?
X58531 laminin alpha 1structural proteins
Z26653 laminin alpha 2structural proteins
L34155 X85108 laminin alpha 3
S78569 laminin alpha 4
Z95636 laminin alpha 5
M61916 laminin beta 1
X79683 laminin beta 2
D37766 laminin beta 3
NM_002293 laminin gamma 1
U31201 laminin gamma 2
AF041835 laminin gamma 3
NM_002295 laminin receptor 1
U11701 LHX2LIM homeodomain trxn factor
U18728 lumicanproteoglycan in ECM of cartilage
U94354 partial lunatic fringe homolog
U22662 LXR alpha
U07132 LXR beta, Ner I
U80811 lysophosphatidic acid receptor EDG2G-prot. coupled receptor
X70326 MacMarcksactin/calmodulin binding prot.
U59423 MADH1TGF-B signaling
U68018 MADH2
U68019 MADH3
NM_005359 MADH4
U73825 MADH5
U59914 MADH6
U94352 maniac fringe homolog
AB000409 map kinase activated prot. kinase
X53331 matrix GLA prot.assoc. w/ matrix of bone + cart.
M13509 matrix metalloproteinase 1 collagenase IV, MMP1
Z48482 matrix metalloproteinase 2, collagenase IV, MMP2
D14043 MGC-24PNA binding glycoprot.
Z29678 MITF (WSIIA)trxn factor
X07820 MMP10matrix metalloproteinase
X57766 MMP11matrix metalloproteinase
L23808 MMP12matrix metalloproteinase
X75308 MMP13matrix metalloproteinase
Z48481 MMP14matrix metalloproteinase
NM_002428 MMP15matrix metalloproteinase
NM_005941 MMP16matrix metalloproteinase
X89576 MMP17matrix metalloproteinase
Y08622 MMP18matrix metalloproteinase
AF056200 MMP23Amatrix metalloproteinase
AJ005256 MMP23Bmatrix metalloproteinase
X05232,AB009303 MMP3matrix metalloproteinase
Z11887 S41832 MMP7, PUMP1matrix metalloproteinase
J05556 MMP8matrix metalloproteinase
D10051 MMP9matrix metalloproteinase
M69066 moesinstructural link between plasma memb. + cytoskel.
AF017655 partial MSA1, spalttrxn factor
M97676 MSX1,msh-like 1, Hox7trxn factor
D26145 MSX2, HOX8trxn factor
X68271 MUC18melanoma assoc. glycoprot.
AF051976 MYO15, DFNB3unconventional myosin
U55208 MYO7A, DFNB2, DFNA1cytoskeletal prot.
U49020 myocyte enhancer factor 2Atrxn factor
L08895 myocyte enhancer factor 2Ctrxn factor
AJ001382 myosin type 1c
S74799 myosin Va
U90236 myosin VI
M34064 N-cadherin
U16799 Na+/K+ ATPase beta 1 subunit
U51478 Na+/K+ trans-porting ATPase beta3 subunit
U16798 Na,K-ATPase alpha 1 (ATP1A1)
J05096 Na,K-ATPase alpha 2 subunit (ATP1A2)
L38500 Na/myo-inositol cotransporter
X15357 natriuretic peptide receptor A
AJ005282 natriuretic peptide receptor Bpeptide receptor
U75330 NCAM2
M14764 nerve growth factor receptor (NGFR)
M94165 neuregulin 1, heregulin alphaglial growth factor
AF045152 NEUROD1trxn factor
U58681 NEUROD2trxn factor
X15306 neurofilament heavy polypeptide (NEFH)cytoskeletal prot.
X05608 neurofilament light polypeptide (NEFL)cytoskeletal prot.
Y00067 neurofilament medium polypeptide
L11353 neurofimbromin 2neurofibromatosis
U63842 neurogenin-1, neuroD3trxn factor
X51956 neuron specific enolase (ENO2)
U45955 neuronal membrane glycoprot. M6neuronal development
U31767 neuronatinpossible regulatory of ion channels
X71445 neurotrophic tyr. kinase,receptor 1 (NTRK1)growth factor receptor
U12140 neurotrophic tyr. kinase,receptor 2 (NTRK2)
U05012 neurotrophic tyr. kinase,receptor 3 (NTRK3)
M37763 neurotrophin 3growth factor
S74017 NF-E2 like basic leucine zippertrxn factor
X52599 NGF
X53655 NGF-2
X65882 norrinextracell. matrix molecule
M73980 NOTCH1memb. prot. receptor
X80115 NOTCH2
X79439 partial NOTCH3
L49171 L49173 L49176 L49170 allOCP-II organ of corti prot.
J04765 osteopontin, secreted phosphoprot. 1extracell. matrix molecule
AF107403 otoferlin, DFNB6,DFNB9cytosolic prot.
AB037501 partial OTX1trxn factor
AB037505 partial OTX2trxn factor
X63629 p-cadherin, m-cadcell -cell adhesion molecule
M17183 parathyroid hormone related protein
X15044 (HuP48)? PAX1trxn factor
M89470 PAX2
S69369 PAX3trxn factor
AF043978 PAX4
U56835 U56836 partial PAX5
M93650 PAX6
Z35141 PAX7
L19606 PAX8
X92850 PAX9
U14588 paxillinECM
AF030880 pendrin, PDSion transporter
D11428 peripheral myelin prot. 22memb. prot. involved in myelinization. CMT
L14565 peripherinstructural prot.
M86400 phospholipase A2activates tyrosine and prot. kinase c
X63741 pilotputative trxn factor
M21574 platelet derived gr. fact. receptor alpha
X02811 platelet derived growth factor B
NM_002607.1 platlet derived gr. fact. Agrowth factor
X52946 pleiotrophinheparin binding mitogenic prot.
L37868 POU3F2trxn factor
AB001835 POU3F3trxn factor
X82324 POU3F4
X64624 POU4F1
U06233 POU4F2
U10061 POU4F3
L42110 presenilin 1AD
L43964 presenilin 2AD
L10678 profilin IIinvolved in actin polymerization
M61900 prostaglandin D synthaseinvolved in making prostaglandinD2-sm. muscle+CNS
X59727 protein kinase related to rat ERK3
M60483 protein phosphatase 2A catalytic subunitmodulates casien kinase,Map2kinase
AF061970 PRX2homeobox trxn factor
U59464 PTCH, pathched homolog
AF087651 PTCH2
X56740 rab11 GTPase
U94353 radical fringe homolog
L02320 radixinECM
X90529 ragAGTP binding prot.
AF012086 Ran binding prot. 2
Y08890 Ran GTP binding prot. 5nuclear transport funct.
X06614 RARAretinoic acid receptor
AF157483 RARB4
X07282 RARE
U51903 RasGAP related prot. IQGAP2potential actin binding domains
U79716 reelinthought to help organize brain structures
X12949 RETReceptor
U35143 Retionblastoma binding prot.negative regulator of ras
L11910 retionblastoma susceptibility genetumor suppressor gene
U43195 Rho-assoc. prot. kinase
U04899 RORA3 , RAR-RELATED ORPHAN RECEPTOR A
Y08639 RORB
X52773 RXRAnuclear receptor
X63522 RXRB
U38480 RXRGretinoid x receptor (gamma)
U83463 scaffold protein Pbp1
AF017986 secreted apop. frizzled related prot. 1
AF017987 secreted frizzled related prot. 2compete w/ frizzled in binding receptor
AF017988 secreted frizzled related prot. 3
L05568 serotonin transporter 5-HT
X91868 SIX1trxn factor
AF092047 SIX3
U09384 SLOslowpoke homolog
AF114821 smoothened homolog
AJ245657 SNAIL 1 homologtrxn factor
U55936 SNAP23
AF115436 SNAP29
L38518 sonic hedgehog
Y13436 SOX1
AJ001183 SOX10
U23752 SOX11
AF116571 SOX13
AF107043 SOX14
Z31560 partial SOX2
AB006867 SOX20
AF107044 SOX21
U35612 SOX22
X71135 SOX3
X70683 SOX4
S83308 SOX5
AF226675 SOX8
Z46629 SOX9
Z30183 SPARCextracell. Ca binding acidic glycoprot.
M77693 spermidine/spermidine N1-acetytransferasecatabolism of poly-amines + transport out of cell
X53305 stathminintracellular prot. involved in 2nd messenger pathway
U26424 Ste-20-like kinase (MST2)ser-thr kinase, MAPK cascade
Z50022 surface glycoproteinputative transmemb. glycoprot.
M36201 J05611 SYB2/VAMP2
AF053233 SYB8, VAMP8
M58378 synapsin 1neuronal phospho-prot. assoc. w/ synaptic ves. memb
AF046873 synapsin 3
X92396 synaptobrevin like protein
M36196 J05611 synaptobrevin, SYB1, VAMP1vesicle assoc. memb. prot.
X06389 Y00507 synaptophysin
D21267 synaptosomal-assoc. prot. (SNAP25)
J05392 syndecan 1
X67016 syndecan 4transmemb. heparan sulfate proteoglycan
L37792 syntaxin 1A (brain)functions in synaptic vesicle fusion
U32315 syntaxin 3
AJ002076 syntaxin 3A
U07158 syntaxin 4A
AJ002078 syntaxin 6
AF000652 synteninpossible adaptor for syndecans and cytoskeleton
AF012131 T box 1
U28049 T box 2trxn factor
U80987 T box 5Holt-Oram Synd
AJ007989 T box 6
L05491 T-plastinactin binding prot.
AF078828 talinECM
U76366 TCOF1nucleoloar trafficking prot.
X99805 tectorin alpha, TECTA, DFNA8, DFNA12
X78565 tenascin ccell adhesion molec.
Z67996 tenascin R
U24488 tenascin XA
X12795 TFCOUP1, v-erbA related prot. ear3trxn factor
M64497 TFCOUP2, ARP 1trxn factor
TGFA
X02812 TGFB1transforming gr. factor
M34057 TGFB1 binding prot.
TGFB2
TGFB3
AF054590 TGFBR1
X77584 thioredoxinredox rxns
L12350 thrombospondin 2glycoprotein involved in cell adhesion, migration
AF126175 partial thyroid hormone receptor betazinc finger trxn factor
X55005 thyroid horomone receptor alpha
Z30183 tissue inhibitor of metallo-proteinases 3inhibitor of collagenases
X03124 tissue inhibitor of metalloproteinase 1
U02571 tissue inhibitor of metalloproteinase 3
M31172 transforming gr. factor alpha
M19154 transforming gr. factor beta 2growth factor
J03241 transforming gr. factor beta3
U04811 trophininmem. prot. cell-cell adhesion + attaches to cytoskeleton
U54644 TUBmutation leads to obesity+ hearing loss in mice
X01703 Tubulin alpha chain
J00314 tubulin beta chain
U82468 TULP1, TUB LIKE
U82469 TULP2
U80998 TWIST
X51420 tyrosine related prot.melanin biosynth.
AF055580 USH2A, usher synd.extracell. matrix molecule
L06328 vacuolar H+ ATPase
U19906 vasopressin V1a receptorarginine vasopressin receptor
D31833 vasopressin V1b receptor
L37112 vasopressin V3 receptor
M25246 vimentincytoplastic intermediate filament prot.
M33308 vinculinECM
L06328 voltage dependent anion channelanion channel
U03106 wild type activated p53 activated frag. 1 (WAF1)expression induced by WT p53
X03072 WNT1wingless homolog, segment polarity
X97057 WNT10B
Y12692 WNT11
Z71621 WNT13
AF028702 partial WNT14
AF028703 partial WNT15
X07876 WNT2
NM_004185.1 WNT2Bsame as wnt 13
L20861 WNT5a
D83175 WNT7a
Y11108 WNT8B


Last updated: January 25, 2002