COGENE is funded by the National Institute of Dental and Craniofacial Research under Contract NO1-DE-92630.

The goals of COGENE are:

1. The development of twelve normalized cDNA libraries that cover many of the early stages of human oral and craniofacial development and their dissemination to the I.M.A.G.E. consortium for conventional EST generation.
2. The development, by intra-library and inter-library subtraction methods, of sub-libraries with a higher frequency of previously undiscovered/differentially expressed cDNAs.
3. The derivation of over 3,000 EST sequences in the course of library validation and subtractive library screening.
4. The production of eleven SAGE libraries from early stages of craniofacial development and the analyses of approximately 50,000 SAGE tags from each of these libraries.
5. The derivation of 1,000 cDNAs and cDNA sequences that correspond to SAGE differences. These sequences will be in addition to the 3,000 sequences mentioned above.
6. The analysis of quantitative changes in the expression of 43,000 genes during 62 different comparative stages of craniofacial development by hybridization of labeled cDNAs to GeneChips.
7. The development of a relational database and web site that contains all the information gathered in this project.